EDUCATION:
• B.S., University of California, Davis, 1960 (Enology).
• D.V.M., University of California, Davis, 1966 (Veterinary Medicine).
• Ph.D., University of California, Davis, 1972 (Comparative Pathology).
• Postdoctoral fellowship, Scripps Research Institute (then Scripps Clinic and Research Foundation),
1972-73 (Immunopathology).
PROFESSIONAL EXPERIENCE:
Managing Member and Co-Founder,
Grant Writers' Seminars and Workshops, LLC, Los Olivos, California, 1994-present.
Wilkinson Distinguished Professor of Cancer Research, University of Kansas
Cancer Center and Department of Pathology and Laboratory Medicine, University
of Kansas Medical Center, Kansas City, KS, 1987-1999; Emeritus, 2000-present
Director, University of Kansas Cancer Center, University of Kansas Medical
Center, Kansas City, KS, 1991-1995.
Visiting Scientist, Howard Hughes Medical Institute, Columbia University,
New York, NY (Sabbatical in laboratory of Dr. Richard Axel), 1988.
Associate Director for Research, University
of Kansas Medical Center, Kansas City, KS, 1987-1991.
Professor and Chairman, Department of Comparative and Experimental Pathology,
College of Veterinary Medicine, and Professor, Departments of Pathology
and of Immunology and Medical Microbiology, College of Medicine, University
of Florida, Gainesville, FL, 1980-87.
Associate Professor of Pathology and of Bacteriology/Immunology, School
of Medicine and Member, Lineberger Comprehensive Cancer Center, University of North
Carolina, Chapel Hill, NC, 1977-80.
Associate, Department of Immunopathology, Scripps Research Institute (then Scripps Clinic and Research
Foundation), La Jolla, CA, 1973-77.
Intern, Angell Memorial Animal Hospital, Boston, MA, 1966-1967.
Quality Control Chemist, Lucky Lager Brewing Company, San Francisco, CA,
1961-62.
Wine Chemist, E&J Gallo Winery, Modesto, CA, 1960-61.
ACADEMIC HONORS AND AWARDS:
• University of California School Medalist (Veterinary Medicine),
1966.
• Special Fellow, United States Public Health Service, 1970-71.
• American Cancer Society, California Division Jr. and Sr. Fellowships,
1974-76.
• Research Career Development Award, United State Public Health
Service, 1976-80.
• Councilor, Society for Leukocyte Biology, 1982-85; 1994-1997.
• President, Association of Veterinary Pathology Chairpersons, 1985-87.
• Beecham Senior Award for Research Excellence, University of Florida,
1986.
• Wilkinson Distinguished Professorship, University of Kansas Medical
Center, 1987
• Phi Zeta Lecturer, College of Veterinary Medicine, Michigan State
University, 1992
• Dolph Simons, Sr. Research Award in the Field of Biomedical Sciences,
Kansas Regents Universities, 1993.
• University of Kansas Medical Center Student Voice Excellence in
Teaching Award, 1995-96
• Alumni Achievement Award, School of Veterinary Medicine, University
of California, Davis, 1996.
• CAAA Citation for Excellence, Cal Aggie Alumni Association, University
of California, Davis, 1996.
• Schofield Memorial Lecturer, Ontario Veterinary College, University
of Guelph, Ontario, Canada, 1996.
EDITORIAL BOARDS AND REVIEW GROUPS:
• Experimental Immunology Study Section, National Institutes of
Health, 1978-83.
• Veterinary Immunology and Immunopathology, 1979-85.
• Journal of Leukocyte Biology, 1979-88.
• Yearbook of Pathology and Clinical Pathology, 1980.
• Journal of Immunology, 1980-82.
• Infection and Immunity, 1980-85.
• Animal Resources Review Committee, National Institutes of Health,
1986-1990 (Chairman, 1989-90).
• Special Review Committee: Animal Models of Solid Tumors, National
Institutes of Health, 1991.
• U.S. Army (D.O.D.) Breast Cancer Research Program, Immunological
Sciences Review Panel, 1995- 1997.
• Board of Scientific Counselors, National Center for Research Resources,
National Institutes of Health, 1995-1998.
• Academic Advisory Committee, Society for Advancement of Chicanos
and Native Americans in Science, 1996-2000.
SOCIETY MEMBERSHIPS AND SPECIALTY BOARDS:
• American Association of Immunologists
• American College of Veterinary Pathologists (Diplomate)
• American Society for Investigative Pathology
ORIGINAL PEER-REVIEWED PUBLICATIONS:
Russell, S.W., Baker, N.F. and Raizes,
G.S.: Experimental Obeliscoides cuniculi infections in rabbits: Comparison
with Trichostronygylus and Ostertagia infections in cattle and sheep.
Exp. Parasitol., 19:163-173, 1966.
Russell, S.W. and Griffiths, R.C.: Recurrence of cervical disc syndrome
in surgically and conservatively treated dogs. J. Am. Vet. Med. Assoc.,
153:1412-1417, 1968.
Slauson, D.O., Gribble, D.H. and Russell, S.W.: A clinicopathological
study of renal amyloidosis in dogs. J. Comp. Pathol., 80:335-343, 1970.
Russell, S.W., Ward, B.C. and Baker, N.F.: Obeliscoides cuniculi: Comparison
of gastric lesions in rabbits with those of bovine ostertagiosis. Exp.
Parasitol., 28:217-225, 1970.
Slauson, D.O., Russell, S.W. and Schecter, R.D.: Naturally occurring immune
complex glomerulonephritis in the cat. J. Pathol., 103:131-133, 1971.
Russell, S.W., Gomez, J.A. and Trowbridge, J.O.: Canine histiocytic ulcerative
colitis. The early lesion and its progression to ulceration. Lab. Invest.,
25:509-515, 1971.
Kurtz, J., Russell, S.W., Lee, J.C., Slauson, D.O. and Schecter, R.D.:
Naturally occurring canine glomerulonephritis. Am. J. Pathol., 67:471-482,
1972.
Russell, S.W., Rosenau, W., Goldberg, M.L. and Kunitomi, G.M.: Purification
of human lymphotoxin. J. Immunol., 109:784-790, 1972.
Russell, S.W., Rosenau, W. and Lee, J.C.: Cytolysis induced by human lymphotoxin.
Cinemicrographic and electron microscopic observations. Am. J. Pathol.,
69:103-118, 1972.
Russell, S.W. and Cochrane, C.G.: The cellular events associated with
regression and progression of murine (Moloney) sarcomas. Int. J. Cancer,
13:54-63, 1974.
Russell, S.W., Francke, U., Buettner, L. and Cochrane, C.G.: Modes of
growth and spread of the transplantable virus-producing murine (Moloney)
sarcoma: karyotypic analyses. J. Natl. Cancer Inst., 53:801-806, 1974.
Russell, S.W., Doe, W.F. and Cochrane, C.G.: Number of macrophages and
distribution of mitotic activity in regressing and progressing Moloney
sarcomas. J. Immunol., 116:164-166, 1976.
Russell, S.W., Doe, W.F., Hoskins, R.G. and Cochrane, C.G.: Inflammatory
cells in solid murine neoplasms. I. Tumor disaggregation and identification
of constituent inflammatory cells. Int. J. Cancer, 18:322-330, 1976.
Russell, S.W., Gillespie, G.Y., Hansen, C.B. and Cochrane, C.G.: Inflammatory
cells in solid murine neoplasms. II. Cell types found throughout the course
of Moloney sarcoma regression or progression. Int. J. Cancer, 18:331,
1976.
Gomez, J.A., Russell, S.W., Trowbridge, J.O. and Lee, J.: Canine histiocytic
ulcerative colitis: An ultrastructural study of the early mucosal lesion.
Am. J. Dig. Dis., 22:485-496, 1977.
Russell, S.W., Gillespie, G.Y. and McIntosh, A.T.: Inflammatory cells
in solid murine neoplasms. III. Cytotoxicity mediated in vitro by macrophages
recovered from disaggregated regressing Moloney sarcomas. J. Immunol.,
118:1574-1579, 1977.
Gillespie, G.Y., Hansen, C.B., Hoskins, R.G. and Russell, S.W.: Inflammatory
cells in solid murine neoplasms. IV. Cytolytic T lymphocytes isolated
from regressing or progressing Moloney sarcomas. J. Immunol., 119:564-570,
1977.
Hansen, C.B., Gillespie, G.Y. and Russell, S.W.: Isolation of T lymphocytes
from disaggregated tumors in high purity with good percentage recovery.
J. Natl. Cancer Inst., 59:273-275, 1977.
Russell, S.W. and McIntosh, A.T.: Macrophages isolated from regressing
Moloney sarcomas are more cytolytic than those recovered from progressing
sarcomas. Nature, 268:69-71, 1977.
Russell, S.W. and Gillespie, G.Y.: Nature, function and distribution of
inflammatory cells in regressing and progressing Moloney sarcomas. J.
Reticuloendothel. Soc., 22:159-168, 1977.
Russell, S.W., Doe, W.F. and McIntosh, A.T.: Functional characterization
of a stable, noncytolytic stage of macrophage activation in tumors. J.
Exp. Med., 146:1511-1520, 1977.
Gillespie, G.Y. and Russell, S.W.: Development and persistence of cytolytic
T lymphocytes in regressing and progressing Moloney sarcomas. Int. J.
Cancer, 21:94-99, 1978.
Gillespie, G.Y., Jensen, F.C. and Russell, S.W.: B-tropic oncornavirus
production by BALB/c methylcholanthrene-induced sarcoma cells. Int. J.
Cancer, 21:234-238, 1978.
Gillespie, G.Y., Hansen, C.B. and Russell, S.W.: Resurgence of killing
and in vivo protection mediated by lymphocytes cultured from lymph nodes
draining Moloney sarcomas. Br. J. Cancer, 38:365-374, 1978.
Esser, A.F. and Russell, S.W.: Membrane perturbation of macrophages stimulated
by lipopolysaccharide. Biochem. Biophys. Res. Comm., 87:532-540, 1979.
Russell, S.W., Jensen, F.C., Vanderlip, J. and Alexander, N.L.: Osteosarcoma
of the mandible of a baboon (Papio papio). Morphological and virological
(oncornavirus) studies, with a review of neoplasms previously described
in baboons. J. Comp. Pathol., 89:349-360, 1979.
Shaw, J.O., Russell, S.W., Printz, M.P. and Skidgel, R.A.: Macrophage-mediated
tumor cell killing: lack of dependence on the cyclooxygenase pathway of
prostaglandin synthesis. J. Immunol., 123:50-54, 1979.
Russell, S.W. and Esser, A.F.: The ability of activated macrophages to
kill tumor cells is independent of membrane fluidity. Biochem. Biophys.
Res. Commun., 89:520-525, 1979.
Long, D.M., Nielson, M.D., Multer, F.K., Lasser, E.C., Liu, M.-S. and
Russell, S.W.: Comparison of radiopaque perfluorcarbon and ethiodol in
lymphography. Radiology, 133:71-76, 1979.
Alexander N., Laurs, R.M., McIntosh, A. and Russell, S.W.: Haematological
characteristics of albacore, Thunnus alalunga (Bonnaterre), and skipjack,
Katsuwonus pelamis (Linnaeus) J. Fish Biol., 16:383-395, 1980.
Russell, S.W., Gillespie, G.Y. and Pace, J.L.: Comparison of responses
made to activating agents by mouse pertioneal macrophages and cells of
the macrophage line RAW 264. J. Reticuloendothel. Soc., 27: 607-619, 1980.
LeBlanc, P.A., Katz, H.R. and Russell, S.W.: A discrete population of
mononuclear phagocytes detected by monoclonal antibody. Infect. and Immun.,
29:520-525, 1980.
Gillespie, G.Y. and Russell S.W.: Level of activation determines whether
inflammatory peritoneal and intratumoral macrophages will promote or suppress
in vitro development of cytolytic T lymphocyte activity. J. Reticuloendothel.
Soc., 27:535, 1980.
Taffet, S.M. and Russell, S.W.: Macrophage-mediated tumor cell killing:
regulation of expression of cytolytic activity by prostaglandin E. J.
Immunol., 126:424-427, 1981.
Pace, J.L., Taffet, S.M. and Russell, S.W.: The effect of endotoxin in
eliciting agents on the activation of mouse macrophages for tumor cell
killing. J. Reticuloendothel. Soc., 30:15-21, 1981.
Pace, J.L. and Russell, S.W.: Activation of mouse macrophages for tumor
cell killing. I. Quantitative analysis of interactions between lymphokine
and lipopolysaccharide. J. Immunol., 126:1863-1867, 1981.
Taffet, S.M., Pace, J.L. and Russell, S.W.: Lymphokine maintains macrophage
activation for tumor cell killing by interfering with the negative regulatory
effect of prostaglandin E2. J. Immunol., 127:121-124, 1981.
Katz, H.R., LeBlanc, P.A. and Russell S.W.: An antigenic determinant shared
by mononuclear phagocytes and mast cells, as defined by monoclonal antibody.
J. Reticuloendothel. Soc., 30:439-443, 1981.
Buhles, W.C., Jr., Vanderlip, J.E., Russell, S.W. and Alexander, N.L.:
Yersinia pseudotuberculosis infection: study of an epizootic in squirrel
monkeys. J. Clin. Microbiol., 13:519-525, 1981.
Wharton, W., Gillespie, G.Y., Russell, S.W. and Pledger, W.J.: Mitogenic
activity elaborated by macrophage-like cell lines acts as competence factor
for BALB/c 3T3 cells. J. Cell. Physiol., 110:93-100, 1982.
Russell, S.W.: Autoregulation of mononuclear phagocyte function. Adv.
Exp. Med. Biol., 155:507, 1982.
LeBlanc, P.A., Russell, S.W. and Chang, S.-M.T.: Mouse mononuclear phagocyte
antigenic heterogeneity detected by monoclonal antibodies. J. Reticuloendothel.
Soc., 32:219-231, 1982.
Taffet. S.M., Eurell, T.E. and Russell, S.W.: Regulation of macrophage-mediated
tumor cell killing by prostaglandins: Comparison of the effects of PGE2
and PGI2. Prostaglandins., 24:763-774, 1982.
Lanier, L.L., Arnold, L.W., Raybourne, R.B., Russell, S.W., Lynes, M.A.,
Warner, N.L. and Haughton, G.: Transplantable B cell lymphomas in B10.H02aH-4b/Wts
mice. Immunogenetics, 16:367-371, 1982.
Pace, J.L., Russell, S.W., Schreiber, R.D., Altman, A. and Katz, D.H.:
Macrophage activation: priming activity from a T cell hybridoma is attributable
to gamma interferon. Proc. Natl. Acad. Sci. (USA), 80:3782-3786, 1983.
Pace, J.L., Russell, S.W., Torres, B.A., Johnson, H.M. and Gray, P.W.:
Recombinant mouse gamma interferon induces the priming step in macrophage
activation for tumor cell killing. J. Immunol., 130:2011-2013, 1983.
Schreiber, R.D., Pace, J.L., Russell, S.W., Altman, A. and Katz, D.H.:
Macrophage activating factor produced by a T cell hybridoma: physiochemical
and biosynthetic resemblance to gamma interferon. J. Immunol., 131:826-832,
1983.
Katz, H.R., LeBlanc, P.A. and Russell, S.W.: Two classes of mouse mast
cells delineated by monoclonal antibodies. Proc. Natl. Acad. Sci. (U.S.A.),
80:5916-5918, 1983.
Russell, S.W and Pace, J.L.: Gamma interferon interferes with the negative
regulation of macrophage activation by prostaglandin E2. Mol. Immunol.,21:249-254,
1984.
Russell, S.W. and Pace, J.L.: Both the kind and magnitude of stimulus
are critical in overcoming the negative regulatory effect of PGE2 on macrophage
activation. J. Leukoc. Biol., 35:291-301, 1984.
Pace, J.L., Russell, S.W., LeBlanc, P.A. and Murakso, D.M.: Comparative
effects of various classes of mouse interferons on macrophage activation
for tumor cell killing. J. Immunol., 134:977-981, 1985.
Leung, K.-P, Russell, S.W., LeBlanc, P.A and Caballero, S.: Heterogeneity
among macrophages cultured from mouse bone marrow. Morphologic, cytochemical
and flow cytometric analyses. Cell and Tissue Res., 239:693-701, 1985.
Pace, J.L., Varesio, L., Russell, S.W. and Blasi, E.: The strain of mouse
and assay conditions dictate whether MuIFN-gamma primes or activates macrophages
for tumor cell killing. J. Leukoc. Biol., 37:475-479, 1985.
Russell, J.K., Hayes, M.P., Carter, J.M., Torres, B.A., Dunn, B.M., Russell,
S.W. and Johnson H.M.: Epitope and functional specificity of monoclonal
antibodies to mouse interferon-gamma: the synthetic peptide approach.
J. Immunol., 136:3324-3328, 1986.
Wechsler, S.J., Eurell, T.E. and Russell, S.W.: Prostaglandin E2 content
of regressing and progressing Moloney sarcomas. J. Leukoc. Biol., 40:159-168,
1986.
MacKay, R.J. and Russell, S.W.: Protein changes associated with stages
of activation of mouse macrophages for tumor cell killing. J. Immunol.,
137:1392-1398, 1986.
Russell, S.W., Pace, J.L., Varesio, L., et al: Comparison of five short
term assays that measure nonspecific cytotoxicity mediated to tumor cells
by activated macrophages. J. Leukoc. Biol., 40:801-813, 1986.
MacKay, R.J. and Russell, S.W.: Protein phenotypes of mouse macrophages
activated in vivo for tumor cell killing. J. Leukoc. Biol., 42:213-221,
1987.
Hayes, M.P., Russell, S.W., Trotta, P.P. and Basu, M.: Enrichment and
initial characterization of the solubilized receptor for mouse gamma interferon.
Biochem. Biophys. Res. Commun., 150:1096-1105, 1988.
Basu, M., Pace, J.L., Pinson, D.M., Trotta, P.P. and Russell, S.W.: Purification
and partial characterization of a receptor protein for mouse gamma interferon.
Proc. Natl. Acad. Sci. (USA), 85:6282-6286, 1988.
MacKay, R.J., Pace, J.L., Jarpe, M.A. and Russell, S.W.: Macrophage activation-associated
proteins: characterization of stimuli and conditions needed for expression
of proteins 47b, 71/73 and 120. J. Immunol., 142:1639-1645, 1989.
Jarpe, M.A., Hayes, M.P., Russell, J.K., Trotta, P.P., Johnson, H.M. and
Russell, S.W.: Casual association of interferon-gamma with tumor regression.
J. Interferon Res., 9:239-244, l989.
Pontzer, C.H. and Russell, S.W.: Culture of macrophages from bovine bone
marrow. Vet. Immunol. and Immunopathol., 21:35l-362, l989.
Basu, M., Pace, J.L., Pinson D.M.
and Russell, S.W.: A monocolonal antibody against the ligand binding site
of the receptor for mouse interferon-gamma. J. Interferon Res., 9:55l-562,
l989.
Pontzer, C.H. and Russell, S.W.: Interferons exhibit temporally distinct
regulation of two bovine macrophage Fc receptors. J. Leukoc. Biol., 47:258-264,
1990.
Chen, T.Y., Bright, S.W., Pace, J.L., Russell, S.W. and Morrison, D.C.:
Induction of macrophage mediated tumor cytotoxicity by a hamster monoclonal
antibody with specificity for lipopolysaccharide receptor. J. Immunol.,
145:8-12, 1990.
Pinson, D.M., Phillips, T.A., Pace, J.L., MacKay, R.J. and Russell, S.W.:
Activation-associated marker proteins: peptide mapping and their expression
in macrophage cell lines. Biochem. Biophys. Res. Commun., 176:882-886,
1991.
Fernando, L.P., LeClaire, R.D., Obici, S., Zavodny, P.J., Russell, S.W.
and Pace, J.L.: Stable expression in rat cells of a secreted form of the
mouse interferon-gamma receptor by rat cells. J. Immunol., 147:541-547,
1991.
LeClaire, R.D., Hunt, J.S., Basu, M., Pinson, D.M., Redick, M.L., Zavodny,
P.J., Pace, J.L. and Russell, S.W.: Characterization and use of monoclonal
and polyclonal antibodies against the mouse interferon-gamma receptor.
J. Leukoc. Biol., 51:507-516, 1992.
Lorsbach, R.B. and Russell, S.W.: A specific sequence of stimulation is
required to induce synthesis of the antimicrobial molecule, nitric oxide,
by mouse macrophages. Infect. Immun., 60:2133-2135, 1992.
Griggs, N., Jarpe, M., Pace, J., Russell, S. and Johnson, H.: The N-terminus
and C-terminus of interferon-gamma are binding domains for cloned soluble
IFN-gamma receptor. J. Immunol., 149:517-520, 1992.
Pinson, D.M., LeClaire, R.D., Lorsbach, R.B., Parmely, M.J. and Russell,
S.W.: Regulation by transforming growth factor-ß1 of expression
and function of the receptor for IFN-gamma on mouse macrophages. J. Immunol.,
149:2028-2034, 1992.
Lorsbach, R.B., Murphy, W.J., Lowenstein, C.J., Snyder, S.H. and Russell,
S.W.: Expression of nitric oxide synthase in mouse macrophages activated
for tumor cell killing: Molecular basis for the synergy between IFN-gamma
and LPS. J. Biol. Chem., 268:1908-1913, 1993.
Lowenstein, C.J., Alley, E.W., Raval, P., Snowman, A.M., Snyder, S.H.,
Russell, S.W. and Murphy, W.J.: Macrophage nitric oxide synthase gene:
Two upstream regions mediate induction by interferon gamma and lipopolysaccharide.
Proc. Natl. Acad. Sci., 90:9730-9734, 1993.
Phillips, T.A., Kujubu, D.A., MacKay, R.J., Herschman, H.R., Russell,
S.W. and Pace, J.L.: The mouse macrophage activation-associated marker
protein, p71/73, is an inducible prostaglandin endoperoxide synthase (cycooxygenase).
J. Biol. Chem. 53:411-419, 1993.
VanVolkenburg, M.A., Griggs, N.D., Jarpe, M.A., Pace, J.L., Russell, S.W.
and Johnson, H.M.: Binding site on the murine IFN-gamma receptor for IFN-gamma
has been identified using the synthetic peptide approach. J. Immunol.,
151:6206-6213, 1993.
Sagi-Assif, O., Douer, D., Shaked, N., Russell, S.W. and Witz, I.P.: Myeloproliferation
in long-term plasmacytoma-regressor mice. Int. J. Cancer 56: 208-213,
1994.
Zhang, X., Alley, E.W., Russell, S.W. and Morrison, D.C.: Necessity and
sufficiency of beta interferon for nitric oxide production in mouse peritoneal
macrophages. Infect. Immun., 62:33-40, 1994.
Bucklin, S.E., Russell, S.W. and Morrison, D.C.: Augmentation of anti-cytokine
immunotherapy by combining neutralizing monoclonal antibodies to interferon-gamma
and the interferon-gamma receptor: protection in endotoxin shock. J. Endotoxin
Res., 1:45-51, 1994.
Fujihara, M., Ito, N., Pace, J.L., Watanabe, Y., Russell, S.W. and Suzuki,
T.: Role of endogenous interferon-ß in lipopolysaccharide-triggered
activation of the inducible nitric oxide synthase gene in a mouse macrophage
cell line, J774. J. Biol. Chem. 269:12773-12778, 1994.
Chen, H.-L., Kamath, R., Pace, J.L., Russell, S.W. and Hunt, J.S.: Gestation-related
expression of the interferon-gamma receptor gene in mouse uterine and
embryonic hematopoietic cells. J. Leukocyte Biol. 55:617-625, 1994.
Chen, H.-L., Kamath, R., Pace, J.L., Russell, S.W. and Hunt, J.S.: Expression
of the interferon-gamma receptor gene in mouse placentas is related to
stage of gestation and is restricted to specific subpopulations of trophoblast
cells. Placenta 15:109-121, 1994.
Bucklin, S.E., Russell. S.W. and Morrison, D.C.: Participation of IFN-gamma
in the pathogenesis of LPS lethality. Prog. Clin. Biol. Res. 388: 399-406,
1994.
Alley, E.W., Zhang, X. and Russell, S.W.: Contribution of clonally distinct
subpopulations to heterogeneous production of inducible nitric oxide synthase
by LPS-stimulated mouse macrophages. J. Endotoxin Res. 1:235-242, 1994.
Pace, J.L., Lowenstein, C.J., Phillips, T.A., Chen, L.-C., Morrison, D.C.,
Hunt, J.S. and Russell, S.W.: Population dynamics of inducible nitric
oxide synthase expression during LPS/IFN-gamma-mediated activation of
mouse macrophages for tumor cell killing. J. Endotoxin Res. 1:227-233,
1994.
Huang, J., Roby, Katherine F., Pace, J.L., Russell, S.W. and Hunt, J.S.:
Cellular localization and hormonal regulation of inducible nitric oxide
synthase in cycling mouse uterus. J. Leukoc. Biology 57:27-35, 1995.
Raval, P., Obici, S., Russell, S.W. and Murphy, W.J.: Characterization
of the 5' flanking region and gene encoding the mouse intereron-gamma
receptor. Gene, 154:219-223, 1995.
Alley, E.W., Murphy, W.J. and Russell, S.W.: A classical enhancer element
responsive to both lipopolysaccharide and interferon-gamma augments induction
of the iNOS gene in mouse macrophages. Gene, 158:247-251, 1995.
Miller, L., Alley, E.W., Murphy, W.J., Russell, S.W. and Hunt, J.S.: Progesterone
inhibits inducible nitric oxide synthase gene expression and nitric oxide
production in murine macrophages. J. Leukoc. Biology, 59, 442-450, 1996.
Zhang, X., Laubach, V.E., Alley, E.W., Edwards, K.A., Sherman, P.A., Russell,
S.W. and Murphy, W.J.: Transcriptional basis for hyporesponsiveness of
the human inducible nitric oxide synthase gene to lipopolysaccharide /
interferon-gamma. J. Leukoc. Biology, 59, 575-585, 1996.
Chen, L-C., Pace, J.L., Russell, S.W. and Morrison, D.C. Altered regulation
of inducible nitric oxide synthase expression in macrophages from senescent
mice. Infection & Immunity, 64, 4288-4298, 1996.
Murphy, W.J., Muroi, M., Zhang, X., Suzuki, T. and Russell, S.W.: Both
a basal and an enhancer gammaB element is required for full induction
of the mouse inducible nitric oxide synthase gene. J. Endotoxin Res.,
3, 381-393, 1997.
Laubach, V.E., Zhang, C.X., Russell, S.W., Murphy, W.J., and Sherman P.A.
Analysis of expression and promoter function of the human inducible nitric
oxide synthase gene in DLD-1 cells and monkey hepatocytes. Biochim. Biophys.
Acta, 1351, 287-295, 1997.
Gao, J., Parmely, T.J., Morrison, D.C., Russell, S.W., and Murphy, W.J.
An interferon-gamma-activated site (GAS) is necessary for full expression
of the mouse iNOS gene in response to interferon-gamma and lipopoysaccharide.
J. Biological Chem. 272:1226-1230, 1997.
Gao, J.J., Filla, M.B., Fultz, M.J., Vogel, S.N., Russell, S.W., and Murphy,
W.J. Autocrine/ paracrine IFN-alpha/beta mediates the lipopolysaccharide-induced
activation of transcription factor Stat1a in mouse macrophages: pivotal
role of Stat1a in induction of the inducible nitric oxide synthase gene.
J Immunol 161:4803-4810, 1998.
Gay, R.D., Dawson, S.J., Murphy, W.J., Russell, S., and Latchman, D.S.
Activation of the iNOS gene promoter by Brn-3 POU family transcription
factors is dependent upon the octamer motif in the promoter. Biochem.
Biophys. Acta 1443:315-322, 1998.
Crowder, C.W., Murphy, W.J., Russell, S.W., and LeBlanc, P.A. Interaction
with vesicular stomatitis virus-infected BALB/c3T3 cells inhibits the
synthesis of nitric oxide in activated murine bone marrow culture-derived
macrophages. J. Leukoc. Biol 65:605-613, 1999.
Crespo, A., Filla, M.B., Russell, S.W., and Murphy, W.J. Indirect induction
of suppressor of cytokine signalling-1 in macrophages stimulated with
bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-alpha/beta.
Biochem J. 349:99-104, 2000.
Gao, J.J., Filla, M.B., Lorsbach, R.B., Pace, J.L., Crespo, A., Russell,
S.W. and Murphy, W.J. Prolonged exposure of mouse macrophages to IFN-ß suppresses transcription of the inducible nitric oxide synthase gene:
altered availability of transcription factor Stat1a. Eur. J. Immunol.
30:1551-1561, 2000.
REVIEW ARTICLES:
Russell, S.W., Gillespie, G.Y. and
Pace, J.L.: Evidence for mononuclear phagocytes in solid neoplasms and
appraisal of their nonspecific cytotoxic capabilities. Contemp. Top. in
Immonobiol., 10:143-166, 1980.
Russell, S.W.: Cytotoxic macrophages: role of lymphokines and prostaglandins
in activation for tumoricidal activity. Chemioterapia Oncologica., 1:34,
1981.
Russell, S.W., Taffet, S.M. and Pace, J.L.: The roles of lymphokine and
prostaglandin in the regulation of mouse macrophage activation for tumor
cell killing. Prog. Cancer Res. Ther., 19:49, 1981.
Russell, S.W.: Problems (technical and interpretive) associated with the
isolation of immune effector cells from tumors. Contemp. Top. in Immunobiol.,
10:1-20, 1980.
Russell, S.W.: T-cell factors regulating macrophage functions, especially
activation for tumor cell killing. Cancer Treatment Symposia., 1:75-81,
1985.
Russell, S.W. and Pace, J.L.: The effects of interferons on macrophages
and their precursors. Vet. Immunol. and Immunopathol., 15:129-165, 1987.
Pinson, D.M. and Russell, S.W.: Colony-stimulating factors and interferons:
their roles in inflammation. In: "Handbook of inflammation. Mediators
of the Inflammatory Process" 6:301-337, l990.
BOOK CHAPTERS:
Russell, S.W., Doe, W.F. and Cochrane,
C.G.: Macrophages in regressing and progressing Moloney sarcomas. In: "The Macrophage in Neoplasia". Academic Press, Inc., New York
(M.A. Fink, Ed.) pp. 199-204, 1976.
Russell, S.W., Doe, W.F. and McIntosh, A.T.: A noncytolytic stage of macrophage
activation in Moloney sarcomas. In: "The Macrophage and Cancer".
Proceedings, European Reticuloendothelial Society, James, K., McBride,
B. and Stuart, A., Eds., Edinburgh. pp. 341-346, 1977.
Russell, S.W.: Obtaining mononuclear phagocytes from disaggregated tumors.
In: "Methods for Studying Mononuclear Phagocytes", D.O. Adams,
P. Edelson, and H. Koren, Eds. Academic Press, Inc. (New York) pp. 231-242,
1981.
LeBlanc, P.A. and Russell, S.W.: Depletion of mononuclear phagocytes or
their functions in vivo or in vitro: pitfalls in the use of carbonyl iron,
carrageenan, silica, trypan blue or antimononuclear phagocyte serum. In: "Methods for Studying Mononuclear Phagocytes", D.O. Adams, P.
Edleson, and H. Koren, Eds. Academic Press, Inc., New York, pp. 231-242,
1981.
Taffet, S.M. and Russell, S.W.: Identification of mononuclear phagocytes
by ingestion of particulate materials, such as erythrocytes, carbon, zymosan
or latex. In: "Methods for Studying Mononuclear Phagocytes",
D.O. Adams, P. Edleson, and H. Koren, Eds. Academic Press, Inc., New York,
pp. 283-293, 1981.
Russell, S.W.: Quantification of cytolysis of neoplastic cells by release
of chromium-51 (51Cr). In: "Methods for Studying Mononuclear Phagocytes",
D.O. Adams, P. Edelson, and H. Koren, Eds. Academic Press, Inc., New York,
pp. 793-799, 1981.
Russell, S.W. and Salomon, D.R.: Macrophage effector and regulatory functions.
In: "Immunity to Cancer". Eds. A.E. Reif and M.S. Mitchell,
Academic Press, Inc. (New York) pp. 205-216, 1985.
Russell, S.W.: Biomolecular mechanisms of macrophage activation for tumor
cell killing. In: "Molecular and Cellular Networks for Cancer Therapy".
Eds. Y. Yamamura and I. Azuma, Excerpta Medica, Ltd. (Tokyo), International
Congress Series #857, pp 45-60, l989.
Wesselius, L.J., Murphy, W.J., Morrison, D.C. and Russell, S.W. Macrophage
activation: concepts and principles applicable to the lung. In: Lung Macrophages
and Dendritic Cells in Health and Disease, Mary F. Lipscomb and Stephen
W. Russell, Eds., Marcel Dekker, Inc., New York, 1997, 33-86.
BOOKS
EDITED:
Macrophage Biology and Activation, Stephen W. Russell and Siamon Gordon,
Springer-Verlag, Berlin, 1992, 299 pp.
Lung Macrophages and Dendritic Cells in Health and Disease, Mary F. Lipscomb
and Stephen W. Russell, eds., Marcel Dekker, Inc., New York, 1997, 855
pp.
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