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David C. Morrison, Ph.D.
Co-Founder and Member
Grant Writers' Seminars and Workshops, LLC
Co-Founder and Member
Grant Writers' Seminars and Workshops, LLC
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EDUCATION:
. 1963 - B.S. Physics, University of Massachusetts, Amherst, MA
. 1969 - Ph.D. Molecular Biology and Biophysics, Yale University, New Haven, CT
. 1969 - 1971 Postdoctoral Fellow, Lab of Biochemical Pharmacology, NIAMD, National Institutes of Health, Bethesda, MD 20014
. 1971 - 1974 Postdoctoral Fellow, Department of Experimental Pathology, Scripps Research Institute (then Scripps Clinic and Research Foundation), La Jolla, CA 92037
PROFESSIONAL EXPERIENCE:
. Visiting Distinguished Professor, Baker University, Nov 2003 - Present
. Member and Co-Founder, Grant Writers' Seminars and Workshops, LLC. 1994 -Present
. Sosland/Missouri Endowed Chair in Trauma Research, University of Missouri-Kansas City School of Medicine (UMKC SOM). May 2001-August 2003
. Adjunct Research Staff, Midwest Research Institute. Jan 2001 - August 2003
. Director of Medical Research, Saint Luke's Hospital of Kansas City; Professor of Basic Medical Science, UMKC SOM. Jan 1999 - August 2003
. Westport Anesthesia Services/Missouri Endowed Chair in Research, Saint Luke's Hospital and UMKC SOM. Jan 1999 - April 2001
. Professor, Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160. May 1985 - Dec 1998
. Associate Director for Basic Research Programs, Cancer Center, University of Kansas Medical Center, Kansas City, KS 66160. July 1991-August 1995
. Chairman, Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160. May 1985 - June 1991
. Professor and Director of Graduate Studies, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322. June 1981-April 1985
. Associate Professor, Department of Microbiology, Emory University School of Medicine, Atlanta, GA 30322. Jan. 1980-May 1981
. Associate Member, Department of Immunology, Scripps Research Institute (then Scripps Clinic and Research Foundation), La Jolla, CA 92037. Oct. 1978 - Dec. 1979
. Associate, Department of Immunopathology, Scripps Research Institute (then Scripps Clinic and Research Foundation), La Jolla, CA 92037. Oct. 1975 - Sept. 1978
. Visiting Scientist, Max Planck Institut for Immunobiologie, Freiburg, West Germany (Professor O. Luderitz). Aug. 1974 - Nov. 1974
. Assistant, Department of Immunopathology, Scripps Research Institute (then Scripps Clinic and Research Foundation), La Jolla, CA 92037. July 1974 - Sept. 1975
ACADEMIC HONORS AND AWARDS:
. Phi Eta Sigma, Freshman Honor Society 1960
. National Science Foundation Undergraduate Research Fellowship 1962
. Hasbrouck Memorial Scholarship in Physics 1963
. Phi Kappa Phi, Senior Honor Society 1963
. B.S. Magna Cum Laude, University of Massachusetts 1963
. Research Career Development Award (NIH) 1975 - 1980
. William P. Timmie Chair in Microbiology (Emory University) 1980 - 1985
. Mid-America State Universities Association Lecturer 1987 - 1988
. Senior Faculty Research Award (KUMC) 1989
. NIH MERIT Award 1990 - 2000
. Innovation in Education Award, School of Medicine (KUMC) 1991
. Excellence in Education Award, School of Medicine (KUMC) 1992
. Honors in Education Award, School of Medicine (KUMC) 1993
. Dolph Simons, Sr. Award for Excellence in Research in the Biomedical Sciences (KU) 1994
. Kansas Masons Distinguished Prof. of Cancer Research (KUMC) 1995 - 1998
. Chancellor's Club Research Award (KUMC) 1997
. Westport Anesthesia Services/Missouri Endowed Chair in Res. 1999 - 2001 (SLH, UMKC)
. Sosland/Missouri Endowed Chair in Trauma Res., UMKC SOM 2001 - Present
EDITORIAL BOARDS AND REVIEW GROUPS / ADVISORY BOARDS:
. Allergy and Immunology Study Section, NIH (Ad Hoc) 1978
. Editorial Board, Journal of Immunological Methods 1978 - 1980
. Minority Biomedical Research Support Program, NIH (Ad Hoc) 1984
. Editorial Board, Immunopharmacology 1979 - 1999
. Editorial Board, Molecular Immunology 1980 - 1983
. Editorial Board, Journal of Immunology 1980 - 1984
. Editorial Board, Infection and Immunity 1980 - 1991
. Bacteriology and Mycology Study Section, NIH 1986 - 1990
. Editorial Board, FEMS Microbiology/Immunology 1987 - 1996
. National Research Council, Predoctoral Advisory Panel 1990 - 1992
. Midwest Multiple Sclerosis Scientific Advisory Board 1990 - 1994
. Wesley Foundation of Wichita, KS 1991 - 1992
. Editor, Immunology Letters 1991 - 1995
. Editorial Board, Journal of Natural Toxins 1991 - 1999
. Bacteriology and Mycology Study Section, NIH (Ad Hoc) 1991, 1993, 1994, 1995
. Editor, Infection and Immunity 1992 - 1994
. Editorial Board, Shock 1993 - 2001
. Founder and Editor in Chief, Journal of Endotoxin Research 1993 - 1998
. Allergy Immunology Transplantation Res.Committee, NIAID/NIH 1995 - 1997
. American Heart Association, National Peer Review Committee, 1999 - 2003
SOCIETY MEMBERSHIPS:
. Sigma XI 1963 - Present
. American Society for Microbiology 1970 - Present
. President, Missouri Valley Branch 1990 - 1991
. American Association for the Advancement of Science 1970 - Present
. American Society of Experimental Pathology 1974
. American Association of Immunologists 1975 - Present
. Society for Leukocyte Biology 1979 - Present
. New York Academy of Science 1979
. Infectious Disease Society of America (Fellow) 1983 - Present
. International Society of Immunopharmacology 1984
. American Academy of Microbiology 1987 - Present
. American Society for Biochemistry and Molecular Biology 1988 - Present
. International Endotoxin Society - Councillor 1988 - 1992
. International Endotoxin Society - Secretary 1992 - 1994
. International Endotoxin Society - President-Elect 1994 - 1996
. International Endotoxin Society - President 1996 - 1998
. International Endotoxin Society - Member 1998 - Present
. Shock Society 1994 - Present
ORIGINAL PEER-REVIEWED PUBLICATIONS:
Morrison, D.C. and Morowitz, H.J. 1970. Studies on membrane synthesis in Bacillus megaterium KM. J. Mol. Biol. 49:441-459.
Chiller, J.M., Skidmore, B.M., Morrison, D.C. and Weigle, W.O. 1973. Relationship of lipopolysaccharide structure to its function in mitogenesis and adjuvanticity. Proc. Natl. Acad. Sci. 70:212.
Morrison, D.C. and Verroust, P. 1973. Anticomplementary activity of lipid A isolated from bacterial lipopolysaccharides. Proc. Soc. Exp. Biol. Med. 143:1024.
Morrison, D.C., Roser, J.F., Henson, P.M. and Cochrane, C.G. 1974. Activation of rat mast cells by low molecular weight stimuli. J. Immunol. 112:573.
Morrison, D.C. and Cochrane, C.G. 1974. Direct evidence for Hageman factor (Factor XII) activation by bacterial lipopolysaccharides (endotoxins). J. Exp. Med. 140:797.
Morrison, D.C. and Leive, L. 1975. Fractions of lipopolysaccharide from Escherichia coli 0111:B4 prepared by two extraction procedures. J. Biol. Chem. 250:2911.
Morrison, D.C., Roser, J.F., Cochrane, C.G. and Henson, P.M. 1975. The initiation of mast cell degranulation: Activation at the cell membrane. J. Immunol. 114: 966-970.
Jacobs, D.M. and Morrison, D.C. 1975. Stimulation of a T-independent primary anti-hapten response in vitro by TNP-lipopolysaccharide. J. Immunol. 114:360.
Skidmore, B.J., Chiller, J.M., Morrison, D.C. and Weigle, W.O. 1975. Immunological properties of bacterial lipopolysaccharides, correlation between the mitogenic, adjuvant and immunologic activities. J. Immunol. 114:360.
Jacobs, D.M. and Morrison, D.C. 1975. Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide (TNP-LPS), a T-independent antigen. J. Exp. Med. 141:1453.
Skidmore, B.J., Morrison, D.C., Chiller, J.M. and Weigle, W.O. 1975. Immunologic properties of LPS. II. The unresponsiveness of C3H/HeJ mouse spleen cells to LPS-induced mitogenesis is dependent on the method used to extract LPS. J. Exp. Med. 142:1488.
Ulevitch, R.J., Cochrane, C.G., Henson, P.M., Morrison, D.C. and Doe, W.F. 1975. Mediation systems in bacterial lipopolysaccharide induced hypotension and disseminated intravascular coagulation. I. The role of complement. J. Exp. Med. 142:1570.
Morrison, D.C., Louis, J.A. and Weigle, W.O. 1976. Dissociation of anticomplementary and adjuvant properties of proteins derived from cobra venom. Immunology. 30:317.
Morrison, D.C. and Jacobs, D.M. 1976. Inhibition of LPS-initiated activation of serum complement by polymyxin B. Infect. Immun. 13:298.
Morrison, D.C., Betz, S.J. and Jacobs, D.M. 1976. Isolation and characterization of the fraction of LPS responsible for mitogenesis of C3H/HeJ spleen cells. J. Exp. Med. 144:840.
Morrison, D.C. and Jacobs, D.M. 1976. Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry. 13:813-818.
Niemetz, J. and Morrison, D.C. 1977. Lipid A as the biologically active moiety in bacterial endotoxin (LPS) initiated generation of procoagulant activity by peripheral blood leukocytes. Blood. 499:47.
Jacobs, D.M. and Morrison, D.C. 1977. Inhibition of the mitogenic response to lipopolysaccharide (LPS) in mouse spleen cells by polymyxin B. J. Immunol. 118:21.
Morrison, D.C. and Kline, L.F. 1977. Activation of the classical and properdin pathways of complement by bacterial lipopolysaccharides. J. Immunol. 118:362.
Goodman, M.G., Morrison, D.C. and Weigle, W.O. 1977. Modulation of lipopolysaccharide (LPS)-mediated function by structural differences of two physically distinct fractions of Escherichia coli K235 LPS. J. Immunol. 118:1852.
Betz, S.J. and Morrison, D.C. 1977. Chemical and biological properties of a protein rich fraction of bacterial lipopolysaccharides. I. The in vitro murine lymphocyte response. J. Immunol. 119:1790.
Ginsberg, M.H. and Morrison, D.C. 1978.The selective binding of aggregated IgG to lipid A rich bacterial lipopolysaccharides. J. Immunol. 120:317.
Morrison, D.C., Roser, J.F., Curry, B.J., Henson, P.M. and Ulevitch, R.J. 1978.Two distinct mechanisms for the initiation of mast cell degranulation. II. A specific inhibition of release by serum proteins. Inflammation. 37:25.
Doe, W.F., Yang, D., Morrison, D.C., Betz, S.J. and Henson, P.M. 1978. Macrophage stimulation by bacterial lipopolysaccharides. II. Evidence for independent differentiation signals delivered by lipid A and by a protein rich fraction of LPS. J. Exp. Med. 148:557-568.
Morrison, D.C. and Betz, S.J. 1977. Chemical and biological properties of a protein rich fraction of bacterial lipopolysaccharides. II. The in vitro rat peritoneal mast cell response. J. Immunol. 119:1790.
Musson, R.A., Morrison, D.C. and Ulevitch, R.J. 1978. Distribution of lipopolysaccharide in LPS-responsive and LPS-unresponsive mice. Infect. Immun. 21:448-457.
Cooper, N.R. and Morrison, D.C. 1978. Direct evidence for activation of purified human complement C1 by bacterial lipopolysaccharides and lipid A. J. Immunol. 120:1862.
Morrison, D.C. 1978. Receptor modulation and mast cell secretion. J. Invest. Dermatol. 71:85-91.
Morrison, D.C., Kline, L.F., Oades, Z.G. and Henson, P.M. 1978. Mechanisms of lipopolysaccharide initiated rabbit platelet response. Infect. Immun. 20:744-751.
Morrison, D.C., and Oades, Z.G. 1979. Mechanism of lipopolysaccharide-initiated rabbit platelet response. II. Evidence that lipid A is responsible for binding of lipopolysaccharide to the platelet. J. Immunol. 122:753-758.
Morrison, D.C. and Curry, B.J. 1979. The use of polymyxin B and C3H/HeJ mouse spleen cells as criteria for endotoxin contamination. J. Immunol. Methods. 27:83-92.
Skelly, R.R., Munkenbeck, P. and Morrison, D.C. 1979. Stimulation of T-independent antibody responses by hapten-lipopolysaccharides without repeating polymeric structures. Infect. Immun. 23:287-293.
Curry, B.J. and Morrison, D.C. 1979. Role of complement in endotoxin-initiated lethality in mice. Immunopharmacology. 1:125-135.
Schreiber, R.D., Morrison, D.C., Podack, E.R. and Muller-Eberhard, H.J. 1979. Bactericidal activity of the alternative complement pathway generated from eleven isolated plasma proteins. J. Exp. Med. 149:870-882.
Skelly, R.R., Munkenbeck, P. and Morrison, D.C. 1980. Immune responses to hapten-lipopolysaccharide conjugates. I. Modulation of in vivo antibody response to the polysaccharide. Cell. Immunol. 49:99-109.
Skelly, R.R., Munkenbeck, P. and Morrison, D.C. 1980. Immune responses to hapten-lipopolysaccharide complexes in mice. II. Characterization of the molecular requirements for the induction of antibody synthesis. J. Immunol. 124:468-473.
Ryan, J.L., Yohe, W.B. and Morrison, D.C. 1980. Stimulation of peritoneal cell arginase by bacterial lipopolysaccharides. Am. J. Pathol. 99:451.
Pangburn, M.K., Morrison, D.C., Schreiber, R.D. and Muller-Eberhard, H.J. 1980. Activation of the alternative complement pathway; recognition of cell surface structures (beta-1H antagonists) by cell bound C3b. J. Immunol. 124:944-98
Oades, Z.G. and Morrison, D.C. 1980. A simple and reproducible method to assess murine platelet responses in vitro. J. Immunol. Methods. 34:79-84.
Izui, S., Morrison, D.C., Curry, B.J. and Dixon, F.J. 1980. Effect of lipid A-associated protein on expression of lipopolysaccharide activity. I. Immunological Activity. Immunology. 40:473-482.
Gronowicz, E.S., Doss, C.A., Howard, F.D., Morrison, D.C., and Strober, S. 1980. Development of an in vitro line of the B cell tumor BCL and its responsiveness to polyclonal B cell activators. J. Immunol. 125:976-980.
Howes, E.L., Jr. and Morrison, D.C. 1980. Lipid A dependence of the ocular response to circulating endotoxin in the rabbit. Infect. Immun. 30:786.
Raziuddin, S. and Morrison, D.C. 1981. Modulation of endotoxin activity of lipopolysaccharides by myelin basic protein. J. Immunol. 126:1030.
Staber, F.G., Habild, W.F., Morrison, D.C. and Taresay, L. 1981. Hemopoietic effects in mice of a lipid A associated protein. Exp. Hematol. 9:264.
Raziuddin, S., Kibler, R.F. and Morrison, D.C. 1981. Prevention of experimental allergic encephalomyelitis by bacterial lipopolysaccharides: Inhibition of cell mediated immunity. J. Immunol. 127:13-16.
Giclas, P.C.,Morrison, D.C., Curry, B.J., Laurs, R.M. and Ulevitch, R.J. 1981. The serum complement system of the albacore tuna, Thunnus alalunga. Comp. Immunol. 5:437-447.
Landes, R.R. and Morrison, D.C. 1981. Biochemical mechanisms of lipid A-mediated enhancement of platelet secretory responses to aggregated immunoglobulins. Am. J. Pathol. 104:196-205.
Raziuddin, S., Kibler, R.F. and Morrison, D.C. 1982. Immunoregulation of experimental allergic encephalomyelitis by lipopolysaccharides. III. In vitro evidence for induction of suppressor cells. J. Immunol. 128:2073.
Raziuddin, S. and Morrison D.C. 1982. Recurrent experimental allergic encephalomyelitis in the lewis rat: The effect of lipopolysaccharide. J. Immunol. 128:1486.
Wilson, M.E., Jones, D.P., Munkenbeck, P. and Morrison, D.C. 1982. Serum dependent and independent effects of bacterial lipopolysaccharides on human neutrophil oxidative capacity in vitro. J. Reticuloendothelial Society. 31:43-57.
Brown, D.E. and Morrison, D.C. 1982. Possible alteration of normal mechanisms of endotoxin toxicity in vivo by Actinomycin D. J. Infect. Disease. 146:746-750.
Lubinsky, S., Munkenbeck, P. and Morrison, D.C. 1983. Interaction of latex insolubilized endotoxins with murine macrophages. I. Phagocytic responses of endotoxin responsive (C3Heb/FeJ) and unresponsive (C3H/HeJ) macrophages in vitro. J. Reticuloendothelial Soc. 33:353-368.
Wilson, M.E. and Morrison, D.C. 1982. Evidence for different physical state requirements for the interaction of lipopolysaccharides with the classical and alternative pathways of complement. Eur. J. Biochem. 128:137-141.
Vukajlovich, S.W. and Morrison, D.C. 1983. Conversion of lipopolysaccharides to molecular aggregates with uniform subunit composition: Demonstration of LPS-responsiveness in endotoxin unresponsive C3H/HeJ B-lymphocytes. J. Immunol. 130:2804-2808.
Skelly, R.R., Ahmed, A., Munkenbeck, P. and Morrison, D.C. 1983. Immune responses to hapten-lipopolysaccharide conjugates in mice. III. Genetics of the antibody response to polysaccharide antigens. J. Immunogenet. 10:237-250.
Carr, C. and Morrison, D.C. 1984. Lipopolysaccharide interaction with rabbit erythrocyte membranes. Infect. Immun. 43:600-606.
Duncan, R.L. and Morrison, D.C. 1984. Fate of Escherichia coli lipopolysaccharide following the uptake of E. coli by murine macrophage in vitro. J. Immunol. 132:1416-1424.
Goodman, S.A. and Morrison, D.C. 1984. Selective association of lipid-rich R like lipopolysaccharide (LPS) subunits with murine spleen cells. Mol. Immunol. 21:689-697.
Pearson, F.C., Bohon, J., Lee, W., Bruzler, G., Sagona, M., Jakobowski, G., Dawe, R., Morrison, D.C. and Dinarello, C. 1984. Characterization of Limulus amoebocyte lysate reactive material from hollow fiber dialyzers. Appl. Environ. Microbiol. 48:1189-196.
Goodman, S.A. and Morrison, D.C. 1985. Lipopolysaccharides receptors on lymphocytes. I. Lack of immunologic recognition of a putative LPS receptor on LPS responder lymphocytes by LPS non-responder mice. J. Immunol. 135:1906-1910.
Carr, C., Jr. and Morrison, D.C. 1985. Mechanisms of polymyxin B mediated lysis of lipopolysaccharide treated erythrocytes. Infect. Immun. 49:84-89.
Vukajlovich, S.W. and Morrison, D.C. 1985. Activation of murine spleen cells by lipid A: Negative modulation of lipid A mitogenic activity by 0-antigen polysaccharide. J. Immunol. 135:2546-2550.
Wollenweber, H.W. and Morrison, D.C. 1985. Synthesis and biochemical characterization of a photoactivatable, iodinatable, cleavable bacterial lipopolysaccharide derivative. J. Biol. Chem. 260:15068-15074
Morrison, D.C., Brown, D.E., Vukajlovich, S.W. and Ryan, J.L. 1985. Ganglioside modulation of lipopolysaccharide initiated complement activation. Mol. Immunol. 22:1169-1176.
Smith, T.F., Alveolet, M. and Morrison, D.C. 1985. The effect of bacterial lipopolysaccharide on histamine release from human basophils. I. Enhancement of Immunologic release by S. minnesota R595 LPS. Clin. Immunol. Immunopath. 34:355-365.
Coleman, D.L., Morrison, D.C. and Ryan, J.L. 1986. Gangliosides block the inhibition of macrophage Fc-dependent phagocytosis by lipopolysaccharide. Cell. Immunol. 100:288-299.
Duncan, R.L., Jr., Hoffman, J., Tesh, V.L. and Morrison, D.C. 1986. Immunological activity of lipopolysaccharides released from macrophages after the uptake of intact E. coli in vitro. J. Immunol. 136:2924-2929.
Hitchcock, P.J., Leive, L., Makela, P.J., Rietschel, E.Th., Strittmatter, W. and Morrison, D.C. 1986. A review of lipopolysaccharide nomenclature - past, present and future. J. Bacteriol. 166:699-705.
Tesh, V.L., Duncan, R.L., Jr. and Morrison, D.C. 1986. The interaction of E. coli with normal human serum. I. The kinetics of serum-mediated lipopolysaccharide release and its dissociation from bacterial killing. J. Immunol. 137:1329-1335.
Ryan, J.L., Gobran, L. and Morrison, D.C. 1986. Modulation of murine macrophage metabolism by glycolipids: Inhibition of LPS-induced metabolism by specific gangliosides. J. Leukoc. Biol. 40:367-379.
Killion, J.W. and Morrison, D.C. 1986. Protection of C3H/HeJ mice to lethal Salmonella typhimurium LT2 infection by immunization with LPS-lipid A associated protein complexes. Infect. Immun. 54:1-8.
Smith, T.F. and Morrison, D.C. 1986. Lack of interference in skin tests by endotoxin in allergin extracts, Ann. Allergy. 57:410-412.
Vukajlovich, S.W., Hoffman, J. and Morrison, D.C. 1987. Activation of human serum complement by bacterial lipopolysaccharides: Structural requirements for antibody independent activation of the classical and alternative pathways. Mol. Immunol. 24:319-331.
Haslett, C., Worthen, G.S., Giclas, P.C., Morrison, D.C., Henson, J.E. and Henson P.M. 1987. The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit. Am. Rev. Respir. Dis. 136:9-18.
Chapes, S.K., Killion, J.W., and Morrison, D.C. 1988. Tumor cell killing and cytostasis by C3H/HeJ macrophages activated in vitro by lipid A-associated protein and interferon gamma. J. Leukoc. Biol. 43: 232-237.
Killion, J.W. and Morrison, D.C. 1988. Mechanisms of murine salmonellosis immunity induced by immunization with lipopolysaccharide-lipid A-associated protein complexes in C3H/HeJ mice. FEMS Microbiol. Immunol. 47:41-54.
Tesh, V.L. and Morrison, D.C. 1988. The interaction of E. coli with normal human serum: Factors affecting the capacity of serum to mediate lipopolysaccharide release. Microb. Pathog. 4:175-187.
Lei, M-G. and Morrison, D.C. 1988. Specific endotoxic lipopolysaccharide binding proteins on murine splenocytes I. Detection of LPS binding sites on splenocytes and splenocyte subpopulations. J. Immunol. 141:996-1005.
Lei, M-G. and Morrison, D.C. 1988. Specific endotoxic lipopolysaccharide binding proteins on murine splenocytes II. Membrane localization and binding characteristics. J. Immunol. 141:1006-1011.
Tesh, V.L. and Morrison, D. C. 1988. The physical chemical characterization and biological activity of serum-released lipopolysaccharides, J. Immunol. 141, 3523-3531. Flebbe, L. Vukajlovich, S.W. and Morrison, D.C. 1989. Immunostimulation of C3H/HeJ lymphoid cells by R-chemotype LPS preparations. J. Immunol. 142:642-652.
Roeder, D., Lei, M-G. and Morrison, D. C. 1989. Specific endotoxic lipopolysaccharide (LPS) binding proteins on lymphoid cells of various animal species: Correlation with endotoxin susceptibility. Infect. Immun. 57:1054-1058.
Silverstein, R., Christoffersen, C. A. and Morrison, D. C. 1989. Modulation of endotoxin lethality in mice by hydrazine sulfate. Infect. Immun. 57:2072-2078.
Ohno, N. and Morrison, D.C. 1989. Lipopolysaccharide Interaction with lysozyme: Binding of LPS to lysozyme and inhibition of lysozyme enzymatic activity. J. Biol. Chem. 264:4434-4441.
Hunt, J.S., Soares, M.J., Lei, M-G., Smith, R.N., Wheaton, D., Atherton, R.A., and Morrison, D.C. 1989. Products of lipopolysaccharide-activated macrophages (tumor necrosis factor-alpha, transforming growth factor-beta) but not lipopolysaccharide modify DNA synthesis by rat trophoblast cells exhibiting the 80 kDa lipopolysaccharide-binding protein. J. Immunol. 143:1606-1613.
Ohno, N. and Morrison, D.C. 1989. Effects of LPS chemotype structure on binding and inactivation of hen egg lysozyme. Eur. J. Biochem. 186:621-627.
Ohno, N. and Morrison, D.C. 1989. Lipopolysaccharide interactions with lysozyme differentially affect LPS immunostimulatory activity. Eur. J. Biochem. 186:629-636.
Bright, S.W., Chen, T-Y., Flebbe, L.M., Lei, M-G., and Morrison, D.C. 1990. Generation and characterization of hamster-mouse hybridomas secreting monoclonal antibodies with specificity for lipopolysaccharide receptor. J. Immunol. 145:1-7.
Chen, T-Y., Bright, S.W., Pace, J.L., Russell, S.W. and Morrison, D.C. 1990. Induction of macrophage mediated tumor cytotoxicity by a hamster monoclonal antibody with specificity for the LPS receptor. J. Immunol. 145:8-12.
Flebbe, L.M., Chapes, S.K. and Morrison, D.C. 1990. Activation of C3H/HeJ macrophage tumoricidal activity and cytokine release by R-chemotype LPS preparations: Differential effects of interferon gamma. J. Immunol. 145:1505-1511.
Morrison, D.C., Silverstein, R., Bright, S.W., Chen, T-Y., Flebbe, L.M. and Lei, M-G., 1990. Monoclonal antibody to the murine lipopolysaccharide receptor protects mice against the lethal effects of endotoxin. J. Infect. Dis. 162:1063-1068.
Silverstein, R., Turley, B.R., Christoffersen, C.A., Johnson, D.C. and Morrison, D.C. 1991. Hydrazine sulfate protects D-galactosamine-sensitized mice against endotoxin and tumor necrosis factor/cachectin lethality. Evidence of a role for the pituitary. J. Exp. Med. 173:357-366.
Miyazuwa, K., Mantel, C., Lu, L., Morrison, D.C. and Broxmeyer, H.E. 1991. Lactoferrin-lipopolysaccharide interactions. Effect of lactoferrin binding to monocyte/macrophage-differentiated HC-60 cells. J. Immunol. 146:723-729.
Lei, M-G., Stimpson, S.A. and Morrison, D.C. 1991. Specific endotoxic lipopolysaccharide-binding receptors on murine splenocytes. III. Binding specificity and characterization. J. Immunol. 147:1925-1932.
Halling, J.L., Hamill, D.R., Lei, M-G., and Morrison, D.C. 1992. Identification and characterization of lipopolysaccharide binding proteins on human peripheral blood cell populations. Infect. Immun. 60:845-852.
Perera, P.Y., Chen, T-Y., Morrison, D.C. and Vogel, S.N. 1992. Detection and analysis of the 80 kDa lipopolysaccharide receptor in macrophages derived from LPSn and LPSd mice. J. Leukoc. Biol. 51:501-506.
Green, S.J., Chen, T-Y., Crawford, R.M., Nacy, C.A., Morrison, D.C. and Meltzer, M.S. 1992. Cytotoxic activity and production of toxic nitrogen oxides by macrophages treated with IFN-alpha and MAb against the 80 kDa LPS receptor. J. Immunol. 149:2069-2075.
Hunt, J.S., Chen, H-L., Hu, X-L., Chen, T-Y. and Morrison, D.C. 1992. Tumor necrosis factor-alpha gene expression in the tissues of normal mice. Cytokine. 4:340-346.
Zhang, C. and Morrison, D.C. 1993. Pertussis toxin-sensitive factor differentially regulates LPS-induced tumor necrosis factor-alpha and nitric oxide production in mouse peritoneal macrophages. J. Immunol. 150:1011-1018.
Kirikae, T., Schade, U., Kirikae, F., Rietschel, E.Th., and Morrison, D.C. 1993. Isolation of a macrophage- like cell line defective in binding of LPS: Influence of serum and LPS polysaccharide chain length on macrophage activation. J. Immunol. 151:2742-2752.
Lei, M.-G., and Morrison, D.C. 1993. Lipopolysaccharide interaction with S2 subunit of pertussis toxin. J. Biol. Chem. 268:1488-1493.
Zhang, X., and Morrison, D.C. 1993. LPS-induced selective primary effects on TNF-alpha and nitric oxide production in mouse peritoneal macrophages. J. Exp. Med. 177:511-516.
Field, S., Pollack, M. and Morrison, D.C. 1993. Development of an antiidiotype monoclonal antibody mimicking an internal image of lipopolysaccharide inner core determinants. Microb. Pathogenesis 15:103-120.
Lei, M.-G., Qureshi, N. and Morrison, D.C. 1993. Lipopolysaccharide (LPS) binding to 73 kDa and 38 kDa surface proteins on lymphoreticular cells: Preferential inhibition of LPS binding to the former by Rhodopseudomonas sphaeroides lipid A. Immunol. Lett. 36:245-250.
Gonzalez, J.C., Johnson, D.C., Morrison, D.C., Freudenberg, M.A., Galanos, C. and Silverstein, R. 1993. Endogenous and exogenous glucocorticoids have different roles in modulating endotoxin lethality in D-galactosamine-sensitized mice. Infect. Immun. 61:970-974.
Lei, M.-G. and Morrison, D.C. 1993. Evidence that lipopolysaccharide and pertussis toxin bind to different domains on the same p73 Receptor on murine splenocytes. Infect. Immun. 61:1359-1364.
Bucklin, S.E., Silverstein, R. and Morrison, D.C. 1993. An Il-6 induced acute phase response does not confer protection against lipopolysaccharide lethality. Infect. Immun. 61:3184-3189.
Zhang, X. and Morrison, D.C. 1993. Lipopolysaccharide structure-function relationship in activation versus reprogramming of mouse peritoneal macrophages. J. Leukoc. Biol. 54:444-450.
Parmely, M.J., Zhou, W-W., Edwards, C., Borcherding, D., Silverstein, R. and Morrison, D.C. 1993. Adenosine and a related analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge. J. Immunol. 151:389-396.
Fujihara, Y., Lei, M.-G., and Morrison, D.C. 1993. Characterization of the specific binding of human IgM monoclonal antibody to LPS and its lipid A domain. Infect. Immun. 61:910-918.
Zhang, X, Alley E., Russell, S.W. and Morrison, D.C. 1994. Necessity and sufficiency of interferon-beta for nitric oxide production in mouse peritoneal macrophages. Infect. Immun. 62:33-40.
Fujihara, Y., Bogard, W.C., Lei, M.-G., Daddona, P.E. and Morrison, D.C. 1993. Monoclonal anti-lipid A IgM antibodies HA-1A and E-5 recognize distinct epitopes on lipopolysaccharide and lipid A. J. Infect. Dis. 168:1429-1435.
Jia, F., Morrison, D.C. and Silverstein, R. 1994. Hydrazine sulfate selectively modulates the TNF response to endotoxin in mouse macrophages. Circ. Shock 42:111-114.
Johnson, D.C., Freudenberg, M.A., Jia, F., Gonzalez, J.C., Galanos, C., Morrison, D.C. and Silverstein, R. 1994. Contribution of tumor necrosis factor-alpha and glucocorticoid in hydrazine sulfate-mediated protection against endotoxin lethality. Circ. Shock 43:1-8.
Bucklin, S.E., Russell, S.W. and Morrison, D.C. 1994. Augmentation of anti-cytokine immunotherapy by combining neutralizing monoclonal antibodies to interferon-gamma and the interferon-gamma receptor: Protection in endotoxin shock. J. Endotoxin Res. 1:45-51.
Bucklin, S.E., Fujihara Y., Leeson, M.C. and Morrison, D.C. 1994. Differential antibiotic-induced release of endotoxin from Gram negative bacteria. Eur. J. Clin. Microbiol. Infect. Dis. Suppl. 1 13:43-51.
Chen, T.-Y., Scott, E. and Morrison, D.C. 1994. Differential effect of serum on LPS-receptor directed activation of mouse macrophages for nitric oxide production. Immunol. Letters 40:179-187.
Leeson, M., Fujihara, Y. and Morrison, D.C. 1994. Evidence for lipopolysaccharide (LPS) as the predominant proinflammatory mediator in supernatants of antibiotic-treated bacteria. Infect. Immun. 62:4975-4980.
Pace, J.L., Lowenstein, C.J., Phillips, T.A., Chen, L.-C., Morrison, D.C., Hunt, J.S. and Russell, S.W. 1994. Population dynamics of inducible nitric oxide synthase expression during LPS-IFN-gamma-mediated activation of mouse macrophages for tumor cell killing. J. Endotoxin Res. 1:227-233.
Field, S. and Morrison, D.C. 1994. An anti-idiotype antibody which mimics the inner-core region of lipopolysaccharide protects mice against a lethal challenge with endotoxin. Infect. Immun. 62:3994-3999.
Field, S. and Morrison, D.C. 1994. A hamster anti-idiotype monoclonal antibody, mimicking the inner-core region of Gram-negative bacterial lipopolysaccharide (LPS), stimulates LPS inner-core-specific serum antibodies in hamsters. J. Endotoxin Res. 1:120-130.
Leeson, M.C. and Morrison, D.C. 1994. Induction of proinflammatory responses in human monocytes by particulate and soluble forms of lipopolysaccharide. Shock 2:235-245.
Kirikae, F., Kirikae, T., Qureshi, N., Takayama, K., Morrison, D.C., and Nakano, M. 1995. CD14 is not involved in Rhodobacter sphaeroides diphosphoryl lipid A inhibition of tumor necrosis factor alpha and nitric oxide induction by taxol in murine macrophages. Infect. Immun. 63:486-497.
Bucklin, S.E., Lake, P., Logdberg, L., and Morrison, D.C. 1995. Therapeutic efficacy of a polymyxin B-dextran 70 conjugate in experimental model of endotoxemia. Antimicrob Agents Chemother 39:1462-1466.
Parmely, M.J., Hao, S.-Y., Morrison, D.C., and Pace, J.L. 1995. Role of macrophage derived nitric oxide in endotoxin lethality in mice. J. Endotoxin Res. 2:45-52.
Bucklin, S.E. and Morrison, D.C. 1995. Differences in therapeutic efficacy among cell wall-active antibiotics in a mouse model of Gram-negative sepsis. J. Infect. Dis. 172:1519-1527.
Hirohashi, N. and Morrison, D.C. 1996. Low dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro. Infect. Immun. 64:1011-1015.
Chen, L.-C., Pace, J.L., Russell, S.W. and Morrison, D.C. 1996. Altered regulation of inducible nitric oxide synthase expression in macrophages from senescent mice. Infec. Immun. 64:4288-4298.
Hirohashi, N., Richards, M., and Morrison, D.C. 1996. Selective effects of serum on bacterial LPS-induced IL-6 and nitric oxide production in mouse peritoneal macrophages. J. Endotoxin Research 3:395-405.
Bucklin, S.E. and Morrison, D.C. 1996. Bacteremia versus endotoxemia in experimental mouse leukopenia--role of antibiotic chemotherapy. J. Infect. Dis. 174:1249-1254.
Gao, J., Morrison, D.C., Parmely, T.J., Russell, S.W. and Murphy, W.J. 1997. An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to inteferon-gamma and lipopolysaccharide. J. Biol. Chem. 272:1226-1230.
Silverstein, R., Norimatsu, N., Morrison, D.C. 1997. Fundamental differences during Gram-positive versus Gram-negative sepsis become apparent during bacterial challenge of D-galactosamine-treated mice. J Endotoxin Research 4:173-181.
Amura, C., Chen, L.-C., Hirohashi, N., Lei, M.-G., and Morrison, D.C. 1997. Two functionally independent pathways exist for LPS-dependent activation of mouse peritoneal macrophages--an effect of human LBP on only one of them. J. Immunol. 159:5079-5083.
Morita, H., Hasunuma, R., Fujihara M., Tanaka, S., Galanos, C., Freudenberg, M.A., Morrison, D.C., Kumazawa, Y. 1997. Measurement of different types of endotoxin in murine plasma by pretreatment with alkaline reagent and kinetic chromogenic Limulus test. J Endotoxin Research 4:339-346.
Amura, C.R., Kamei, T., Ito, N., Soares, M.J., and Morrison, D.C. 1998. Differential regulation of LPS activation pathways in mouse macrophages by LPS binding proteins. J. Immunol. 161:2551-2560.
Norimatsu, M., and Morrison, D.C. 1998. Correlation of antibiotic induced endotoxin release and cytokine production in Escherichia coli-inoculated mouse whole blood ex vivo. J. Infect. Dis. 177:1302-1307.
Shnyra, A., Brewington, R., Alipio, A., Amura, C.R., and Morrison, D.C. 1998. Reprogramming of LPS-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12. J. Immunol. 160:3729-3736.
Amura, C.R., Silverstein, R., and Morrison, D.C. 1998. Mechanisms involved in the pathogenesis of sepsis are not necessarily reflected by in vitro cell activation studies. Infect. Immun. 66:5372-5378.
David, S.A., Silverstein, R., Amura, C.R., Kielian, T., Morrison, D.C. 1999. Lipopolyamines: novel antiendotoxin compounds that reduce mortality in experimental sepsis caused by Gram-negative bacteria. Antimicrob Agents Chemoth 43: 912-919.
Gao JJ, Zuvanich EG, Xue Q, Horn DL, Silverstein R, Morrison DC. 1999. Cutting Edge: Bacterial DNA and lipopolysaccharide act in synergy in inducing nitric oxide production in RAW 264.7 macrophages. J Immunol 163:4095-4099.
Hirohashi N, Lei, M-G, Morrison DC. 1999. LPS pretreatment of mouse peritoneal macrophages differentially modulates TNF-a and iNOS expression. J Endotoxin Research 5:251-260.
Horn, D.L., Morrison, D.C., Opal, S.M., Silverstein R., Visvanathan, K., and Zabriskie, J.B. 2000. What are the microbial components implicated in the pathogenesis of sepsisgamma Report on a Symposium. Clin Infect Dis. 31:851-858.
Luchi M, Morrison DC. 2000. Comparable endotoxic properties of lipopolysaccharides are manifest in diverse clinical isolates of gram-negative bacteria. Infect Immun. 68:1899-1904.
Silverstein R, Wood JG, Xue Q, Norimatsu M, Horn DL, Morrison DC. 2000. Differential host inflammatory responses to viable vs. killed bacteria in experimental microbial sepsis. Infect Immun 68:2301-2308.
Luchi M, Morrison DC, Opal S, Yoneda K, Slotman G, Changers H, Wiesenfeld W, Lemke J, Ryan JL, Horn D, and the urosepsis study group. 2000. A comparative trial of imipenem versus Ceftazidime in the release of endotoxin and cytokine generation in patients with gram-negative urosepsis. J Endotoxin Research 6:25-31.
Lei M-G, Morrison DC. 2000. Differential expression of caveolin-1 in lipopolysaccharide-activated murine macrophages. Infect. Immun. 68:5084-5089.
Gao JJ, Xue Q, Zuvanich EG, Haghi KR, Morrison DC. 2000. Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro. Infect Immun. 69:751-757.
Cui W, Morrison DC, Silverstein R. 2000. Differential TNF-alpha expression and release from peritoneal mouse macrophages in vitro in response to proliferating gram-positive vs. gram-negative bacteria. Infect Immunol. 68:4422-4429.
Chi L, Li Y, Stehno-Bittel L, Gao J, Morrison DC, Stechschulte DJ, Dileepan KN. 2001. Interleukin-6 production by endothelial cells via protease-activated receptor stimulation is synergized by endotoxin and tumor necrosis factor-a. J Cytokine Res. In press.
Gao JJ, Xue Q, Papasian CJ, Morrison DC. 2001. Bacterial DNA and LPS induce synergistic production of TNF-alpha through a post-transcriptional mechanism. J Immunol. 166:6855-6860.
Opal SM, Palardy JE, Parejo N, Morrison DC. 2001. Lipopolyamines as a therapeutic strategy in experimental Gram-negative bacterial sepsis. J Endotoxin Research 7:36-38.
BOOK CHAPTERS:
Morrison, D.C. 1961. Theoretical strength of metals. Engineering Journal, University of Massachusetts.
Leive, L. and Morrison, D.C. 1972. Isolation of lipopolysaccharides from bacteria. In: Methods of Enzymology (V. Ginsberg, ed.), Academic Press, New York, Vol. 28, pp. 254-262.
Cochrane, C.G., Revak, S.D., Wuepper, K.D., Johnston, A., Morrison, D.C. and Ulevitch R.J. 1974. Activation of Hageman factor and the kinin forming, intrinsic clotting and fibrinolytic systems. In: Advances in the Biosciences 12 (G. Raspe and S. Bernhare, eds.), Pergamon Press, Vieweg, p. 237.
Cochrane, C.G., Revak, S.D.., Wuepper, K.D., Johnston, A., Morrison, D.C. and Ulevitch, R.J. 1974.Soluble mediators injury of the microvasculature: Hageman factor and the kinin forming intrinsic clotting the fibrinolytic systems, Microvascular Research, 8:112.
Ulevitch, R.J., Cochrane, C.G., Revak, S.D., Morrison, D.C. and Johnston, A.R. 1974. The structure and enzymatic properties of the components of Hagemen factor activated pathway. Cold Spring Harbor Conference on Cell Proliferation, Volume II. In: Proteases and Biological Control, 1974, pp. 85-93.
Jacobs, D.M. and Morrison, D.C. 1976. Lymphocyte triggering by bacterial LPS. Dissociation between immunogenicity of TNP-LPS and mitogenesis and complement- activating properties. In: Leukocyte Membrane Determinants Regulating Immune Reactivity (V.P. Elijsvoogel, D. Roos, W.O. Zeijlemaker, eds.) Academic Press, New York, pp. 89-96.
Morrison, D.C., Henson, P.M. and Cochrane, C.G. 1976. The activation of inflammatory cells in immunologic disease. In: Infection and Immunology in the Rheumatic Disease, Symposium on Rheumatic Disease, London, (D.C.. Dumonde, ed.) Blackwell Scientific Press, pp. 355-563.
Morrison, D.C., Henson, P.M. and Cochrane, C.G. 1976. Two independent recognition sites for initiation of histamine release from mast cells. In: Leukocyte Membrane Regulating Immune Reactivity (V.P. Elijsvogel, D. Roos, W.O. Ziejlmaker, eds.) Academic Press, New York, pp. 551-562.
Ulevitch, R.J., Morrison, D.C., Cochrane, C.G. and Henson, P.M. 1976. Complement independent lipopolysaccharide-induced hypotension and disseminated intravascular coagulation: A correlation of LPS structure with in vivo and in vitro biological activities. In: Advances in Experimental Medicine and Biology, Vol. 73A (S.M. Reichard, M.R. Escobar and H. Freidman, eds.) Plenum Press, New York, pp. 339-349.
Cochrane, C.G., Revak, S.D., Ulevitch, R.J., Johnston, A. and Morrison, D.C. 1977. Hageman factor, characterization mechanism of activation. In: Chemistry and Biology of the Kallikerin-Kinin System in Health and Disease (J. Pisano and K.F. Austen, eds.) Government Press, p. 17.
Betz, S.J., Morrison, D.C. and Jacobs, D.M. 1977. Identification and characterization of the chemical moiety of LPS responsible for C3H/HeJ spleen cell mitogenicity. In: Regulatory Mechanisms in Lymphocyte Activation (D.O. Lucas, ed.) Academic Press, New York, p. 319.
Ulevitch, R.J., Cochrane, C.G., Morrison, D.C. and Henson, P.M. 1977. Complement and LPS-induced hypotensive shock. Proceedings of the International Symposium of Immunopathology, Bas Schachen, Switzerland, pp. 262-281.
Morrison, D.C., Laurs, R.M. and Ulevitch, R.J. 1978. Activity of albacore tuna serum complement reflects its ability to thermoregulate. In: The Physiological Ecology of Tunas (G.D. Sharp and A.E. Dizon, eds.) Academic Press, New York, pp. 141-150.
Laurs, R.M., Ulevitch, R. and Morrison, D.C. 1978. Estimates of blood volume in the albacore tuna, Thunnus alalunga. In: The Physiological Ecology of Tunas, (G.D. Sharp and E.E. Dixon, eds.) Academic Press, New York, pp. 135-139. Morrison, D.C. and Roser, J.F. 1979. The modulation of mast cell secretion. Dermatology Digest, pp. 51-52.
Morrison, D.C., Oades, Z.G. and Betz, S.J. 1980. The role of lipid A and lipid A-associated protein in cell degranulation mechanisms. In: Natural Toxins (D. Eaker and T. Wadstrom, eds.) Pergamon Press, Vieweg, pp. 287-294.
Morrison, D.C., Wilson, M.E., Raziuddin, S., Betz, S.J., Curry, B.J., Oades, Z.G. and Munkenbeck, P. 1980. The influence of lipid A-associated protein on endotoxin stimulation of non-lymphoid cells. In: Microbiology, 1980 (D. Schlessinger, ed.) American Society of Microbiology, Washington, D.C. pp. 30-35.
Wilson, M.E., Munkenbeck, P., Curry, B.J., Oades, Z.G. and Morrison, D.C. 1981. Influence of bacterial endotoxins on neutrophilic leukocytes: Lack of a correlation between in vivo and in vitro responses. In: Progress in Clinical and Biological Research: Pathophysiological Effects of Endotoxin at the Cellular Level (J.A. Majde and R.M. Person, eds.) Alan R. Liss, Inc., New York, pp. 157-172.
Morrison, D.C., Oades, Z.G. and DiPietro, D. 1980. Lipid A mediated perturbation of mammalian cell membranes. In: Bacterial Endotoxins (M.K. Agarwal, ed.) Elsevier North Holland, Biomedical Press, Amsterdam, pp. 311-325.
Morrison, D.C., Oades, Z.G. and DiPietro, D. 1981. Endotoxin induced platelet membrane perturbation.In: Progress in Clinical and Biological Research: Pathophysiological Effects of Endotoxins at the Cellular Level (J.A. Majde and R.M. Person, eds.) Alan R. Liss, Inc., New York, pp. 47-64.
Morrison, D.C. 1982. Molecular targets for endotoxin induced host responses. In: The Pathogenesis of Microbial Infections (C.C. Janson, ed.) American Society of Microbiology, Washington, D.C., pp. 23-26.
Carr, C. and Morrison, D.C. 1984. A two step mechanism for the interaction of Re-LPS with erythrocyte membranes. Rev. Infect. Dis. 6:497-500.
Vukajlovich, S.W. and Morrison, D.C. 1984. Lipid A dependent lymphocyte proliferation in "endotoxin-nonresponder" mice. Rev. Infect. Dis. 6:528-531.
Goodman, S.A., Vukajlovich, S.W., Munkenbeck, P. and Morrison, D.C. 1984. Selective interaction of lipid A subunits in LPS-Macromolecular aggregates with lymphocytes. Rev. Infect. Dis. 6:511-518.
Morrison, D.C., Oades, Z.G., Vukajlovich, S.J., Goodman, S.A. and Duncan, R.L. 1984. Mechanism of action of endotoxin at the cellular level. In: Mechanisms of Hepatocyte Injury and Death (D. Keppler, ed.) MTP Press, Lancaster, pp. 225-241.
Morrison, D.C., Vukajlovich, S.W., Goodman, S.A. and Wollenweber, H-W. 1985. Regulation of lipopoly-saccharide biological activity by polysaccharide. In: Pathogenesis of Bacterial Infection, Proc. Grosse Ledder Symposium VIII, (G.G. Jackson and H. Thomas, eds.) Springer-Verlag, Berlin, pp. 68-84.
Morrison, D.C., Duncan, R.L., Jr. and Goodman, S.A. 1985. In vivo biological activities of endotoxin. In: Proc: of the International Conference on Endotoxin Assays (H.R. Buller, J.W. TenCate and A. Sturk, eds.) Elsevier North Holland, Amsterdam, pp. 81-99.
Duncan, R.L. and Morrison, D.C. 1985. Activity of macrophage processed endotoxin. In: Pathogenesis of Bacterial Infection, Proc. Grosse Ledder Symposium VIII (G.G. Jackson and H. Thomas, eds.) Springer-Verlag, Berlin, pp. 392-297.
Morrison, D.C., Wollenweber, H.W., Vukajlovich, S.W. and Goodman, S.A. 1986. Biochemical, immunological and functional analysis of lymphocytes from the LPS non-responder C3H/HeJ mouse. In: Immunobiology and Immunopharmacology of Bacterial Endotoxins (A. Szentivanyi, H. Freidman and A. Nowotny, eds.) Plenum Press, New York, pp. 315-327.
Duncan, R.L., Jr., Tesh, V. and Morrison, D.C. 1986. Characterization and localization of lipopolysaccharides following the ingestion of E. coli by murine macrophages in vitro. In: Immunobiology and Immunopharmacology of Bacterial Endotoxins (A. Szentivanyi, H. Friedman and A. Nowotny, eds.) Plenum Press, New York, pp. 359-367.
Morrison, D.C., Vukajlovich, S.W., Ryan, J.L. and Levin, J. 1987. Structural requirements for gelation of the Limulus amoebocyte lysates by endotoxin. In: Proc. 2nd International Conference on Endotoxins and Their Detection With the Limulus Amoebocyte Lysate Test (J. Levin and S.E. Waterson, eds.) Alan R. Liss Inc., New York, pp. 55-73.
Morrison, D.C. 1986. The C3H/HeJ mouse strain: It's role in the elucidation of host response to bacterial endotoxin. In: Microbiology (P. Bonventre, ed.) ASM Publications, Washington, D.C., pp. 23-28.
Vukajlovich, S.W., Sinoway, P. and Morrison, D.C. 1986. Activation of human serum complement by bacterial lipopolysaccharides. EOS-J. Immunol. Immunopharmacol. 6S:73-75.
Morrison, D.C., Vukajlovich, S.W., Page, K. and Wollenweber, H-W. 1986. Lipopolysaccharide interactions mediating B-lymphocyte activation. EOS-J. Immunol. Immunopharmacol. 6S:83-85.
Tesh, V.L., Vukajlovich, S.W., and Morrison, D.C. 1988. Endotoxin Interactions with Serum Proteins: Relationship to Biological Activity In: Bacterial Endotoxins: Pathophysiological Effects, Clinical Significance and Pharmacological Control (J. Levin, J.W. TenCate, A. Sturk, and H.R. Buller, eds.) Alan R. Liss, Inc. New York, pp. 47-62.
Ohno, N. and Morrison, D.C. 1989. Structural Specificity of the Binding of Bacterial Lipopolysaccharide (LPS) to Hen Egg Lysozyme. In: The Immune Response to Structurally Defined Proteins: The Lysozyme Model (S. Smith-Gill and E. Sercarz, eds.) Adenine Press (NY) pp. 97-105.
Lei, M-G., Flebbe, L., Roeder, D. and Morrison, D.C. 1990. Identification and Characterization of Lipopolysaccharide Receptor Molecules on Mammalian Lymphoid Cells. In: Endotoxin. (H. Friedman, T.W. Klein, M. Nakano and A. Nowotny, eds.) Plenum Publishing Co., New York, pp. 445-466.
Lei, M-G., Chen, T-Y. and Morrison, D.C. 1990. Lipopolysaccharide receptors on mammalian lymphoreticular cells. In: International Reviews of Immunology. (E. Jirillo, ed.) Harwood Academic Pub., New York, pp. 223-235.
Morrison, D.C. 1990. Diversity of mammalian macromolecules which bind bacterial endotoxins. In: Proc. First International Endotoxin Society Symposium. (A. Nowotny, J. Spitzer and E. Ziegler, eds.) Elsevier North Holland, Biomedical Press, Amsterdam, pp. 183-189.
Chen, T-Y., Lei, M-G., Suzuki, T. and Morrison, D.C. 1992. Lipopolysaccharide receptors and signal transduction pathways in mononuclear phagocytes. In: Macrophage Biology and Activation. (S. Gordon and S. W. Russell, eds.) Springer Verlag Inc., Heidelberg, pp. 169-188.
Morrison, D.C., Silverstein, R., Lei, M-G., Chen, T-Y., and Flebbe, L.M. 1992. Bacterial Endotoxins - Structure, Function and Mechanism of Action. In: Natural Toxins: Toxicology, Chemistry and Safety. (A. Tu, R. Keeler and N. Mandava, eds.) Alakan Inc., Fort Collins, CO, pp. 301-315.
Morrison, D.C., Lei, M.-G., Chen, T.-Y., Flebbe, L.M., Halling, J. and Field, S. 1992. Identification and characterization of mammalian cell membrane receptors for LPS- endotoxin. In: Microbial Infections: Role of Biological Response Modifiers. (H. Friedman, T. Klein and H. Yamaguchi, eds.) Plenum Press, New York, pp. 23-29.
Morrison, D.C., Silverstein, R. and Parmely, M. 1992. Novel approaches to the therapeutic treatment of septic shock. In: Yearbook on Intensive Care and Emergency Medicine, Springer-Verlag, Vol. 4, pp. 91-101.
Lei, M.-G., and Morrison, D.C. 1993. Interrelationship of LPS, pertussis toxin and the p73 LPS receptor on lymphoreticular cells. In: Bacterial Endotoxin: Recognition and Effector Mechanisms, Proc. Second Int. Endotoxin Society Symposium (J. Levin, C.R. Alving, R.S. Munford and P.L. Stütz, eds.) Elsevier Science Publishers B.V., pp. 143-150. Morrison, D.C., Lei, M.-G.,
Kirikae, T., and Chen, T.-Y. 1993. Endotoxin receptors on mammalian cells. Immunobiology, 187:212-226. Kirikae, T., Lei, M.-G., Chen, T. and Morrison D.C. 1994. Interactions of endotoxins with membranes and membrane receptors. In: Endotoxin and the Lungs (K.L. Brigham, ed), Marcel Dekker, New York, pp. 21-44.
Morrison, D.C., Dinarello, C.A., Munford, R.S., Natanson, C., Pollack, M., Spitzer, J.J., Ulevitch, R.J.,Vogel, S.N. and McSweegan, E. 1994. Bacterial Endotoxins and Pathogenesis of Gram Negative Infections: Current Status and Future Direction. Report of a workshop sponsored by the Bacterial Pathogenesis Program, Division of Microbial Infectious Diseases, NIAID, NIH, July 27, 1993. J. Endotoxin Research. 1:71-83.
Morrison, D.C. and Bucklin, S.E. 1995. Endotoxemia, bacteremia and the pathogenesis of Gram-negative sepsis. In: Differential Release and Impact of Antibiotic-Induced Endotoxins (E. Faist, ed), Merck & Co. Inc., Whitehouse Station, New Jersey, pp. 37-46.
Morrison, D.C., Kirikae, T., Kirikae, F., Lei, M.-G., Chen, T. and Vukajlovich, S. 1994. The Receptor(s) for endotoxin on mammalian cells. In: Bacterial Endotoxins (J. Levin, S.J.H. van Deventer, T. van der Poll, A. Sturk, eds), Wiley-Liss, New York, pp. 3-15.
Parmely, M.J., Hausmann, E.H.S., and Morrison, D.C. 1995. Carbocyclic nucleosides as potential therapeutic agents for the treatment of septic shock. In: Novel Therapeutic Strategies in the Treatment of Sepsis (D.C. Morrison, J.L. Ryan, eds), Marcel Dekker Inc., New York.
Qureshi, N., Takayama, K., Hofman, J., Vogel, S.N., and Morrison, D.C. 1995. Diphosphoryl lipid A from Rhodobacter sphaeroides: A novel lipopolysaccharide antagonist. In: Novel Therapeutic Strategies in the Treatment of Sepsis (D.C. Morrison, J.L. Ryan, eds), Marcel Dekker Inc., New York.
Field, S.K., Pollack, M., and Morrison, D.C. 1995. Anti-idiotype monoclonal antibodies as LPS internal images and immunologic protection against endotoxin lethality in mice. In: Haemophilus, Actinobacillus, and Pasteurella (W. Donachie et al, eds), Plenum Press, New York.
Shnyra, A.A., Hirohashi, N., Lei, M.-G., Ware, J., and Morrison, D.C. 1996. LPS-dependent, CD14-independent scavenger receptor activation pathway for proinflammatory cytokine responses in rat Kupffer cells and endothelial liver cells. In: Proceedings of the 3rd International Symposium on Immune Consequences of Sepsis and Shock (E. Faist, A.E. Baue, F.W. Schildberg, eds.), Pabst Science Publishers, Berlin, pp. 839-846.
Morrison, D.C., Bucklin, S.E., Leeson, M.C. and Norimatsu, N. 1996. Contribution of soluble endotoxin released from Gram-negative bacteria by antibiotics to the pathogenesis of experimental sepsis in mice. J. Endotoxin Research, 3:237-244.
Bucklin, S.E. and Morrison, D.C. 1996. Bacteremia vs endotoxemia in an experimental animal model of Gram-negative sepsis. In: Shock--From Molecular and Cellular Level to Whole Body (K. Okada and H. Ogata, eds), Elsevier Publishing Co., Tokyo, pp. 85-95.
Morrison, D.C., and Bucklin, S.E. 1996. A Review: Evidence for antibiotic-mediated endotoxin release as a contributing factor to lethality in experimental Gram-negative sepsis. Scand. J. Inf. Dis. S101:3.
Alipio, A., Morrison, D.C., Shnyra, A. 1997. Selective immunoregulatory cytokines reproduce low dose LPS reprogramming of mouse macrophages. In: Proceedings of the 4th International Congress on the Immune Consequences of Trauma, Shock and Sepsis (E. Faist, ed.), Monduzzi Editore S.p.A, Bologna, Italy, pp. 321-326.
Morrison, D.C. 1997. Antibiotics, endotoxin, and the pathogenesis of Gram-negative sepsis. In: Proceedings of the Symposium Antibiotic-Induced Endotoxin Release--Potential Contribution to the Pathophysiology of Sepsis. Presented at the 4th International Congress on the Immune Consequences of Trauma, Shock and Sepsis, Merck & Co. Inc., Whitehouse Station, NJ, pp. 1-4.
Norimatsu, M., and Morrison, D.C. 1997. Correlation of ex vivo and in vivo effect of antibiotics in experimental E. coli sepsis. In: Proceedings of the Symposium Antibiotic-Induced Endotoxin Release--Potential Contribution to the Pathophysiology of Sepsis. Presented at the 4th International Congress on the Immune Consequences of Trauma, Shock and Sepsis, Merck & Co. Inc., Whitehouse Station, NJ, pp. 35-39. .
Kirikae, T., Nakano, M., Morrison, D.C. 1997. Antibiotic-induced endotoxin release and its clinical significance. Minophagen Medical Review 42:1-54 (Japanese). Morrison, D.C. 1997. Endotoxin and the septic patient - differential contribution of antibiotic therapygamma Infections in Oncology, November 1997, Innovative Medical Communications, Dallas, TX.
Morrison, D.C. 1998. Antibiotic-mediated release of endotoxin and the pathogenesis of Gram-negative sepsis. In: Progress in Clinical and Biological Research, Vol 397. Endotoxin and Sepsis--Molecular Mechanisms of Pathogenesis Host Resistance and Therapy. Proceedings of the 4th Conference of the International Endotoxin Society, Nagoya, Japan, October 23-27, 1996 (J. Levin, M. Pollack, T. Yokochi, M. Nakano, eds.), Wiley-Liss, New York, pp. 199-207.
Morrison, D.C., Silverstein, R., Luchi, M. and Shnyra, A. 1999. Structure-function relationships of bacterial endotoxins: contribution to microbial sepsis. In: Bacterial Sepsis and Septic Shock, (S.M. Opal and A.S. Cross, eds.), Infectious Disease Clinics of North America, pp. 313-340.
Shnyra, A., Luchi, M., and Morrison, D.C. 2000. Preparation of endotoxin from pathogenic gram negative bacteria. In: Methods in Molecular Medicine: Septic Shock Methods and Protocols (T. Evans, ed.), Humana Press Inc., Totowa, NJ., pp. 13-25.
Shnyra, A., Luchi, M, Gao, J.J., Papasian, C., Horn D.L., Silverstein, R., and Morrison, D.C. Endotoxin in human disease and its endogenous control. In: Multiple Organ Failure (A. Baue, E. Faist, D. Fry, eds.) Springer Verlag, NY, pp 114-130, 2000.
Papasian C, Morrison DC. 2001. The pathogenesis of Gram-negative sepsis. In: Sepsis, JL Vincent, J Carlet, S Opal (eds), Kluwer Academic Publishers. In press.
REVIEW ARTICLES:
Morrison, D.C. and Henson, P.M. 1977. Release of mediators from mast cells and basophils induced by different stimuli. In: Modern concepts and developments in immediate hypersensitivity. (M.K. Bach, ed.) Academic Press, New York, pp. 431-502.
Henson, P.M., Ginsberg, M.H. and Morrison, D.C. 1978. Mechanisms of mediator release from inflammatory cells. In: Membrane Fusion (G. Poste and G.L. Nicolson, eds.) A.S.P. Biological and Medical Press, B.V. Amsterdam-West, The Netherlands, pp. 407-508.
Morrison, D.C. and Ulevitch, R.J. 1978. A Review - The interaction of bacterial endotoxins with cellular and humoral mediation systems. Am. J. Path. 92:527-618.
Morrison, D.C. and Ryan, J.L. 1979. A Review - Bacterial endotoxins and host immune function. In: Advances in Immunology, Vol. 28 (F.J. Dixon and H.G. Kunke, eds.) Academic Press, New York, pp. 293-450.
Morrison, D.C. and Rudbach, J.A. 1981. Endotoxin-cell membrane interactions leading to transmembrane signals. In: Contemporary Topics in Molecular Immunology, Vol. 8 (W.J. Mandy and F.P. Inman, eds.) Plenum Publishing Co., New York, pp. 187-218.
Morrison, D.C. and Raziuddin, S. 1982. Lipopolysaccharides and endotoxins. In: Research Monographs in Immunology, Vol. VII Immunopharmacology (P. Sirois and Rola-Pleszcynski, eds.) Elsevier North Holland, Amsterdam, pp. 169-199.
Morrison, D.C. 1983. Bacterial endotoxins and pathogenesis. In:Reviews of Infectious Diseases. 5:S733-47.
Hitchcock, P.J. and Morrison, D.C. 1984. The protein component of bacterial endotoxins. In: Chemistry of Endotoxin (E. Th. Rietschel, ed.) Elsevier North Holland, Amsterdam, pp. 339-375.
Morrison, D.C. 1985. Nonspecific interactions of bacterial lipopolysaccharides with membranes and membrane components. In: Cellular Biology of Endotoxins (L.J. Berry, ed.) Elsevier North Holland, Amsterdam, pp. 25-55.
Morrison, D.C. and Ryan, J.L. 1987. Endotoxins and Disease Mechanisms. In: Annual Rev. Medicine, ed. W.P. Creger Ann. Reviews Inc., Palo Alto, CA, pp. 417-432.
Morrison, D.C. 1989. Minireview: The Case for Specific Lipopolysaccharide Receptors Expressed on Mammalian Cells. Microbial Pathogenesis 7:389-398.
Morrison, D.C., Danner, R.I., Dinarello, C.A., Munford, R.S., Natanson, C., Pollack, M., Spitzer, J.J., Ulevitch, R.J., Vogel, S.N., and McSweegan, E. 1994. Bacterial endotoxins and pathogenesis of Gram-negative infections: current status and future direction. J. Endotoxin Research 1:71-83.
Kirikae, T., Nakano M. and Morrison, D.C. 1997. A Review - Antibiotic-induced endotoxin release and its clinical significance. In: Microbiology and Immunology, 41:285-294.
Wesselius, L.J., Murphy, W.J., Morrison, D.C., Russell, S.W. 1997. Macrophage Activation. In:Lung Macrophages and Dendritic Cells in Health and Disease (MF Lipscomb, SW Russell, eds.), pp 33-86.
BOOKS EDITED:
Morrison, D.C. and Ryan, J.L. (eds.) 1992. Bacterial Endotoxic Lipopolysaccharides. I. Molecular Biochemistry and Cell Biology, CRC Press Inc., Boca Raton, FL.
Ryan, J.L. and Morrison, D.C. (eds.) 1992. Bacterial Endotoxic Lipopolysaccharides. II. Pathophysiology and Pharmacology, CRC Press Inc., Boca Raton, FL.
Morrison, D.C. and Ryan, J.L. (eds.) 1995. Novel Therapeutic Strategies in the Treatment of Sepsis. Marcel Dekker Inc., New York, NY.
Brade, H., Opal, S.M., Vogel, S.N. and Morrison, D.C. (eds.) 1999. Endotoxin in Health and Disease, Marcel Dekker Inc., New York, NY, pp 950.
PATENTS:
U.S. Patent #5,045,466: "Purified Mammalian Cell Binding Receptor for Bacterial Lipopolysaccharide Endotoxin and Monoclonal Antibody", issued September 3, 1991.
U.S. Patent #5,998,482: "The Use of Synthetic Polycationic Amphiphilic Substances with Fatty-Acid or Hydrocarbon Substituents as Anti-Sepsis Agents," issued December 7, 1999.
U.S. Patent #6,172,220: "Isolated Algal Lipopolysaccharides and Use of Same to Inhibit Endotoxin- Initiated Sepsis," issued January 9, 2001.